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KMID : 0360220090500121824
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 12 p.1824 ~ p.1830
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Electrophysiological and Morphological Changes After Intravitreal Bevacizumab Injection with Macular Edema or Choroidal Neovascularization
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Lee Hyun-Joon
Park Joo-Youn
Ohn Young-Hoon
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Abstract
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Purpose: To evaluate the functional and anatomical statuses of macula with multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) for the treatment of patients with macular edema after intravitreal bevacizumab injection.
Methods: Patients were injected with intravitreal bevacizumab (1.875 mg/0.075 ml) for macular edema with choroidal neovascularization (CNV), diabetic retinopathy and retinal vein occlusion. The mfERG and OCT were performed. The results of mfERG were divided into fovea (Ring 1) and parafovea (Ring 2), and amplitude and implicit time were compared. The central macular thickness of OCT and visual acuity were compared with parameters of mfERG.
Results: A total of 120 eyes (96 patients) were diagnosed with diabetic retinopathy, CNV with age-related macular degeneration and retinal vein occlusion. Visual acuity improved from logMAR 0.85±0.39 to 0.54±0.38 after intravitreal bevacizumab injection. The implicit time of P1 and N2 in mfERG decreased, and the amplitude of P1 showed a statistically significant increase. Central macular thickness decreased from 374.4±135.2 μm to 249.0±72.0 μm.
Conclusions: After intravitreal bevacizumab injection, functional and anatomical statuses of mfERG and OCT improved. This study demonstrates a method for utilizing mfERG to assess the effectiveness of treatments such as bevacizumab.
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KEYWORD
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Choroidal neovascularization, Intravitreal Bevacizumab injection, Macular edema, Multifocal electroretinogram
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